Basophils in pruritic skin diseases

Basophils are rare cells in the peripheral blood which have capability to infiltrate into skin. Invasion of basophils has been detected pruritic skin diseases, including atopic dermatitis, bullous pemphigoid, chronic spontaneous urticaria and contact dermatitis. In skin, important players inflammatory immune response, as they release Th2 cytokines, interleukin (IL)-4 IL-13, subsequently inducing early activation T-cells. Further, a multitude mediators, such histamine IL-31, both play an role initiation response via sensory nerves. Chronic pruritus significantly affects quality life working patients, though its mechanisms not fully elucidated yet. Since neurons share many receptors channels, bidirectional interaction mechanisms, drive sensation itch, highlighted this review.